ALPS Medical Breakthroughs ETF (SBIO) holdings & weights
Per-holding contribution · concentration · sector skew — a deep read
Fund overview
This is a US-listed ETF from SS&C. It tracks the S-Network Medical Breakthroughs Index. Key facts — expense ratio 0.5%; net assets about $180M; inception Dec 31, 2014. Its 1-year return is +23.52%.
Fund details
Fund overview
This is a US-listed ETF from SS&C. It tracks the S-Network Medical Breakthroughs Index. Key facts — expense ratio 0.5%; net assets about $180M; inception Dec 31, 2014. Its 1-year return is +23.52%.
25 identified stocks · net exposure / NAV 57.97%. Display weights are normalized to 100%; calculations retain original exposures without an additional leverage multiplier. Cash and unallocated contracts are excluded from stock attribution.
Weight and calculation basis
25 identified stocks · net exposure / NAV 57.97%. Display weights are normalized to 100%; calculations retain original exposures without an additional leverage multiplier. Cash and unallocated contracts are excluded from stock attribution.
We have this ETF's holdings, but the prices for those particular listings are outside our quote coverage (currently Korea- and US-listed securities). So today's contribution and return are not computed — showing 0% would claim it did not move, which is a different statement. The holdings and weights below follow the calculation basis above.
Today's summary
Its top 10 holdings make up about 53.7% of the fund. The concentration index (HHI) is 444 — Low — evenly diversified, and the largest sector is Health Care (100%). The higher the concentration, the more one stock or sector drives the whole ETF's return.
Structural health
A five-axis read on how this fund is built. It is not a return forecast or a recommendation, and a low score does not mean a bad fund — leveraged products score low by design. Each axis shows the figure behind it.
Concentration is below 1,500 (444), so no single holding dominates.
Health Care alone is 100%. This is effectively a bet on that one industry — if the sector falls, diversification will not help.
0.5% a year is typical. Held ten years, roughly 5.0% goes to fees.
Net assets of $180M — liquid enough to trade, and unlikely to be wound down.
A plain 1x physical fund holding the shares themselves — no structural drift from how long you hold it.
Concentration and diversification
Structural health
A five-axis read on how this fund is built. It is not a return forecast or a recommendation, and a low score does not mean a bad fund — leveraged products score low by design. Each axis shows the figure behind it.
Concentration is below 1,500 (444), so no single holding dominates.
Health Care alone is 100%. This is effectively a bet on that one industry — if the sector falls, diversification will not help.
0.5% a year is typical. Held ten years, roughly 5.0% goes to fees.
Net assets of $180M — liquid enough to trade, and unlikely to be wound down.
A plain 1x physical fund holding the shares themselves — no structural drift from how long you hold it.
Top 20 holdings
Weights are normalized to 100% of absolute exposures across analysed positions, including positions outside this top list. Cash, collateral and unverified assets are excluded. Contributions retain original signed NAV exposures; leverage is not applied twice.
Normalized to 100% of analysed positions
Weights are normalized to 100% of absolute exposures across analysed positions, including positions outside this top list. Cash, collateral and unverified assets are excluded. Contributions retain original signed NAV exposures; leverage is not applied twice.
| # | Holding | Weight |
|---|---|---|
| 1 | CG OncologyCGON | 6.76% |
| 2 | Oruka TherapeuticsORKA | 6.26% |
| 3 | Travere TherapeuticsTVTX | 6.19% |
| 4 | VeradermicsMANE | 5.85% |
| 5 | Definium TherapeuticsDFTX | 5.67% |
| 6 | Dianthus TherapeuticsDNTH | 5.16% |
| 7 | Edgewise TherapeuticsEWTX | 4.95% |
| 8 | Relay TherapeuticsRLAY | 4.61% |
| 9 | Amylyx PharmaceuticalsAMLX | 4.17% |
| 10 | Acadia PharmaceuticalsACAD | 4.09% |
| 11 | Xenon PharmaceuticalsXENE | 4.05% |
| 12 | IDEAYA BiosciencesIDYA | 4.02% |
| 13 | Tarsus PharmaceuticalsTARS | 3.92% |
| 14 | Denali TherapeuticsDNLI | 3.52% |
| 15 | Dyne TherapeuticsDYN | 3.47% |
| 16 | Zai LabZLAB | 3.12% |
| 17 | SELLAS Life SciencesSLS | 2.95% |
| 18 | NewAmsterdam PharmaNAMS | 2.95% |
| 19 | MBX BiosciencesMBX | 2.90% |
| 20 | Celldex TherapeuticsCLDX | 2.69% |
Holdings below 0.5% or outside the top list are folded into “Others” and omitted above.
Where the weight sits — sector mix
Listed equity weights summed by sector and normalized to 100%. Each band is one sector's share.
Industry breakdown
HHI sums the squared weights. The more it leans on a few names, the higher it goes — and the more the whole ETF moves with them.
How concentrated is it
Concentration (HHI) is low at 444, with the top 10 holdings at just 53.7% of equity weight. No single name can dominate the fund.
Good for damping single-stock risk — and equally, a big winner inside gets diluted.
HHI squares each weight and sums them: 10,000 means one stock is everything, and the more evenly spread the holdings, the closer it falls to zero.
Where the sector weight sits
By sector, Health Care alone is 100% — whatever the fund is called, this is a bet on that industry.
Bad news for the sector moves the whole fund. Worth checking against anything else you hold in the same space.
Weights above sum the individually listed equities and normalize that equity total to 100%.
How much it overlaps others
Even its closest peer, IBRN, overlaps only 16% (5 shared names).
Funds filed under the same label can hold quite different companies, so pairing this one with another may genuinely spread risk.
What it is made of
The fund holds 104 positions in total; this page lists the largest 25 and folds the rest into "Others".
Equities are 58.0% of the fund, the rest swaps and cash — index exposure built synthetically rather than by owning the shares, which adds counterparty risk.
The expense ratio is 0.5% a year, which is not cheap. Fees come out of returns every year you hold, so it is worth checking whether the same index is available for less.
This page is not investment advice. Investment decisions and responsibility are your own.
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